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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619757 Species: Rattus norvegicus RGD Object: Gene Symbol: Acox1 Name: acyl-CoA oxidase 1, palmitoyl

Acc ID: CHEBI:39421 Term: perfluorooctane-1-sulfonic acid Definition: An organofluorine compound that has formula C8HF17O3S. CasRN: 1763-23-1 Chemical ID: MESH:C076994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:732685	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:19429403 PMID:21705711
multiple interactions	EXP		6480464	CTD	[perfluorooctane sulfonic acid results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein	PMID:15071170
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:18692542 PMID:19162173 PMID:19407336 PMID:19429409 PMID:18923995
increases expression	ISO	RGD:732685	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:21705711 PMID:19429403
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:19162173 PMID:19407336 PMID:18923995 PMID:19429409 PMID:18692542
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:19407336 PMID:19429409 PMID:18692542 PMID:18923995 PMID:19162173
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:18923995 PMID:21723365 PMID:19407336 PMID:18692542 PMID:19162173 PMID:19429409
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:19407336 PMID:18923995 PMID:18692542 PMID:21723365 PMID:19429409 PMID:19162173
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:18923995 PMID:19429409 PMID:18692542 PMID:19407336 PMID:19162173 PMID:21723365
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:18692542 PMID:18923995 PMID:19162173 PMID:19407336 PMID:19429409 PMID:21723365
increases expression	ISO	RGD:732685	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of ACOX1 mRNA	PMID:19429403 PMID:20936131 PMID:21705711