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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of UGT1A1 mRNAPMID:19045937 PMID:37148813
Ugt1a1decreases expressionISOUGT1A1 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of UGT1A1 mRNAPMID:31809754
Ugt1a1increases expressionISOUgt1a1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of UGT1A1 mRNAPMID:32979393
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of UGT1A1 mRNAPMID:32253466 PMID:35337807
Ugt1a1multiple interactionsISOUgt1a1 (Mus musculus)6480464CTD[Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of UGT1A1 mRNA; [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of UGT1A1 protein; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UGT1A1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of UGT1A1 mRNAPMID:32979393 PMID:36331819
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