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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of PTK2 mRNAPMID:20136073
Ptk2decreases response to substanceISOPTK2 (Homo sapiens)6480464CTDPTK2 protein mutant form results in decreased susceptibility to perfluorooctane sulfonic acidPMID:29150642
Ptk2increases expressionISOPtk2 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of PTK2 proteinPMID:26178269
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