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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ACSL1 mRNAPMID:18692542
Acsl1affects expressionISOAcsl1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid affects the expression of ACSL1 mRNAPMID:19429403
Acsl1increases expressionISOAcsl1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of ACSL1 mRNA; perfluorooctane sulfonic acid results in increased expression of ACSL1 proteinPMID:20936131 PMID:21705711 PMID:32979393
Acsl1multiple interactionsISOAcsl1 (Mus musculus)6480464CTD[Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of ACSL1 mRNA; [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ACSL1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of ACSL1 mRNA; perfluorooctane sulfonic acid promotes the reaction [Dietary Fats results in increased expression of ACSL1 protein]PMID:32979393 PMID:36331819
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