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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:39421 Term: perfluorooctane-1-sulfonic acid Definition: An organofluorine compound that has formula C8HF17O3S. CasRN: 1763-23-1 Chemical ID: MESH:C076994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:708379	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA	PMID:19162173 PMID:18692542 PMID:16221955
increases expression	ISO	RGD:708379	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA	PMID:18692542 PMID:16221955 PMID:19162173
multiple interactions	EXP		6480464	CTD	perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone]	PMID:21964418
increases expression	EXP		6480464	CTD	perfluorooctane sulfonic acid results in increased expression of CYP3A4 mRNA	PMID:21723365
increases expression	ISO	RGD:708379	6480464	CTD	perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA	PMID:16221955 PMID:18692542 PMID:19162173