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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3651
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl12increases expressionISOCXCL12 (Homo sapiens)6480464CTDCoumestrol results in increased expression of CXCL12 mRNAPMID:19167446 PMID:23384675 PMID:28396216
Cxcl12multiple interactionsISOCXCL12 (Homo sapiens)6480464CTD[Coumestrol co-treated with ESR1 protein] results in increased expression of CXCL12 mRNA; [Coumestrol co-treated with resveratrol] results in increased expression of CXCL12 mRNA; ESR1 protein inhibits the reaction [Coumestrol results in increased expression of CXCL12 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CXCL12 mRNA]PMID:18310284 PMID:19167446 PMID:23384675
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