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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2245
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1c
Name: calcium voltage-gated channel subunit alpha1 C
Acc ID: CHEBI:38940
Term: sunitinib
Definition: A pyrrole that has formula C22H27FN4O2.
Chemical ID: MESH:C473478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1cdecreases activityISOCACNA1C (Homo sapiens)6480464CTDsunitinib results in decreased activity of CACNA1C proteinPMID:23707608
Cacna1cdecreases expressionISOCACNA1C (Homo sapiens)6480464CTDSunitinib results in decreased expression of CACNA1C mRNAPMID:31533062
Cacna1cdecreases expressionISOCacna1c (Mus musculus)6480464CTDSunitinib results in decreased expression of CACNA1C proteinPMID:31025080
Cacna1cmultiple interactionsISOCacna1c (Mus musculus)6480464CTDPIK3CA protein inhibits the reaction [Sunitinib results in decreased expression of CACNA1C protein]PMID:31025080
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