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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:38561 Term: rel-(3R,5S)-fluvastatin Definition: null CasRN: 93957-54-1 Chemical ID: MESH:C065180

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]	PMID:16029222
decreases activity	EXP		6480464	CTD	fluvastatin results in decreased activity of CYP3A4 protein	PMID:16029222