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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDfumonisin B1 results in increased expression of TP53 proteinPMID:28181396
Tp53multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Aflatoxin B1 promotes the reaction [fumonisin B1 results in increased expression of TP53 protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Aflatoxin B1 results in increased expression of TP53 protein]]; Aflatoxin B1 promotes the reaction [fumonisin B1 results in increased expression of TP53 protein]; fumonisin B1 promotes the reaction [Aflatoxin B1 results in increased expression of TP53 protein]PMID:28181396
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDfumonisin B1 results in decreased expression of TP53 mRNAPMID:27757495
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[fumonisin B1 results in decreased chemical synthesis of Ceramides] which affects the splicing of and results in decreased expression of TP53 mRNA; [fumonisin B1 results in decreased chemical synthesis of Ceramides] which results in decreased phosphorylation of TP53 protein modified formPMID:25195822
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