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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620766 Species: Rattus norvegicus RGD Object: Gene Symbol: Tmprss2 Name: transmembrane protease, serine 2

Acc ID: CHEBI:379896 Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. CasRN: 965-93-5 Chemical ID: MESH:D015741

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1354092	6480464	CTD	Metribolone results in decreased expression of TMPRSS2 mRNA	PMID:12711008
increases expression	ISO	RGD:1354092	6480464	CTD	Metribolone results in increased expression of TMPRSS2 mRNA	PMID:21440447 PMID:17010675
multiple interactions	ISO	RGD:1354092	6480464	CTD	Dapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA]	PMID:21440447
increases expression	ISO	RGD:1354092	6480464	CTD	Metribolone results in increased expression of TMPRSS2 mRNA	PMID:17010675 PMID:21440447