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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605729 Species: Homo sapiens RGD Object: Gene Symbol: HMGB1 Name: high mobility group box 1

Acc ID: CHEBI:379896 Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. CasRN: 965-93-5 Chemical ID: MESH:D015741

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Metribolone results in decreased expression of HMGB1 protein	PMID:17152098