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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359326 Species: Rattus norvegicus RGD Object: Gene Symbol: Uxt Name: ubiquitously-expressed, prefoldin-like chaperone

Acc ID: CHEBI:379896 Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. CasRN: 965-93-5 Chemical ID: MESH:D015741

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1347196	6480464	CTD	Metribolone promotes the reaction [UXT protein binds to ATR promoter] Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter] Metribolone promotes the reaction [UXT protein binds to KLK3 promoter] Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter] UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA] UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA] UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]	PMID:19318562
affects response to substance	ISO	RGD:1347196	6480464	CTD	UXT protein affects the susceptibility to Metribolone	PMID:19318562