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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313354 Species: Homo sapiens RGD Object: Gene Symbol: NKX3-1 Name: NK3 homeobox 1

Acc ID: CHEBI:379896 Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors. CasRN: 965-93-5 Chemical ID: MESH:D015741

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Dapsone analog inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]	PMID:21440447
multiple interactions	EXP		6480464	CTD	Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer] Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]	PMID:16603237
multiple interactions	EXP		6480464	CTD	Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter] Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter] UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]	PMID:19318562
decreases expression	EXP		6480464	CTD	Metribolone results in decreased expression of NKX3-1 mRNA	PMID:12711008
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:17010675 PMID:17131305 PMID:19318562 PMID:17202838 PMID:21440447
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 protein	PMID:17303007
multiple interactions	EXP		6480464	CTD	TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]	PMID:17202838
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:21440447 PMID:17202838 PMID:19318562 PMID:17131305 PMID:17010675
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:21440447 PMID:19318562 PMID:17202838 PMID:17131305 PMID:17010675
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:17010675 PMID:17202838 PMID:19318562 PMID:17131305 PMID:21440447
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:17202838 PMID:17010675 PMID:21440447 PMID:19318562 PMID:17131305
multiple interactions	EXP		6480464	CTD	bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]	PMID:11751618
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:11751618 PMID:17131305 PMID:17202838 PMID:21440447 PMID:17010675 PMID:19318562
increases expression	EXP		6480464	CTD	Metribolone results in increased expression of NKX3-1 mRNA	PMID:11751618 PMID:17010675 PMID:17131305 PMID:17202838 PMID:19318562 PMID:21440447