GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c6 | affects abundance | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene polymorphism affects the abundance of clopidogrel metabolite | PMID:20217574 | Cyp2c6 | affects response to substance | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrel | PMID:17900275 PMID:18532997 PMID:19429918 PMID:19463375 PMID:19706858 PMID:19926050 PMID:19934793 PMID:20166430 PMID:20180610 PMID:20620727 PMID:20978260 | Cyp2c6 | decreases metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrel | PMID:17900275 PMID:19106084 | Cyp2c6 | decreases response to substance | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrel | PMID:17697139 PMID:19106084 PMID:19576320 | Cyp2c6 | increases metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased metabolism of clopidogrel | PMID:18532997 | Cyp2c6 | increases oxidation | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased oxidation of clopidogrel | PMID:19812348 | Cyp2c6 | increases response to substance | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrel | PMID:19496924 PMID:20083681 | Cyp2c6 | multiple interactions | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | ABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel] | PMID:16772608 PMID:18577829 PMID:19106083 PMID:19170597 PMID:19812348 PMID:19926050 PMID:19934793 PMID:20180610 | |
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