Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6affects abundanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene polymorphism affects the abundance of clopidogrel metabolitePMID:20217574
Cyp2c6affects response to substanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene affects the susceptibility to clopidogrel; CYP2C19 gene polymorphism affects the susceptibility to clopidogrel; CYP2C19 gene SNP affects the susceptibility to clopidogrelPMID:17900275 PMID:18532997 PMID:19429918 PMID:19463375 PMID:19706858 PMID:19926050 PMID:19934793 PMID:20166430 PMID:20180610 PMID:20620727 PMID:20978260
Cyp2c6decreases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene polymorphism results in decreased metabolism of clopidogrel; CYP2C19 gene SNP results in decreased metabolism of clopidogrelPMID:17900275 PMID:19106084
Cyp2c6decreases response to substanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene polymorphism results in decreased susceptibility to clopidogrel; CYP2C19 gene SNP results in decreased susceptibility to clopidogrelPMID:17697139 PMID:19106084 PMID:19576320
Cyp2c6increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased metabolism of clopidogrelPMID:18532997
Cyp2c6increases oxidationISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased oxidation of clopidogrelPMID:19812348
Cyp2c6increases response to substanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene polymorphism results in increased susceptibility to clopidogrel; CYP2C19 gene SNP results in increased susceptibility to clopidogrelPMID:19496924 PMID:20083681
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTDABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; CYP2C19 gene affects the reaction [clopidogrel affects the phosphorylation of VASP protein]; CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene polymorphism results in decreased metabolism of and results in decreased activity of clopidogrel; CYP2C19 gene SNP promotes the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]; CYP2C19 protein results in increased metabolism of and results in increased activity of clopidogrel; CYP2C19 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite; CYP2C9 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]; N-3-benzylnirvanol inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of clopidogrel]; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]PMID:16772608 PMID:18577829 PMID:19106083 PMID:19170597 PMID:19812348 PMID:19926050 PMID:19934793 PMID:20180610
Go Back to source page   Continue to Ontology report