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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityEXP 6480464CTDClotrimazole results in increased activity of NR1I2 proteinPMID:23899473 PMID:27732639
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDClotrimazole results in increased activity of NR1I2 proteinPMID:12065438 PMID:15548381 PMID:16919048 PMID:23899473 PMID:25680588 PMID:26187274 PMID:28259787
Nr1i2increases activityISONr1i2 (Mus musculus)6480464CTDClotrimazole results in increased activity of NR1I2 proteinPMID:12049174 PMID:16919048
Nr1i2increases expressionISONR1I2 (Homo sapiens)6480464CTDClotrimazole results in increased expression of NR1I2 mRNAPMID:17998298
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDClotrimazole binds to and results in increased activity of NR1I2 protein; Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]PMID:12695351 PMID:14977870 PMID:15849716 PMID:17998298 PMID:20869355 PMID:27507784
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