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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621238
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1bincreases expressionISOTNFRSF1B (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of TNFRSF1B proteinPMID:10072544
Tnfrsf1bmultiple interactionsISOTNFRSF1B (Homo sapiens)6480464CTD[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA; NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1B protein]PMID:10072544 PMID:15477007
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