Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of NFE2L2 proteinPMID:20438634
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of NFE2L2 mRNAPMID:24632381
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NFE2L2 protein; Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]]; Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of NFE2L2 protein]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFE2L2 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]; Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of NFE2L2 proteinPMID:24632381
Go Back to source page   Continue to Ontology report