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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k2increases phosphorylationISOMAP2K2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 proteinPMID:20479004
Map2k2multiple interactionsISOMAP2K2 (Homo sapiens)6480464CTD[Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MAP2K2 protein; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP2K2 mRNA; PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP2K2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]PMID:11861786 PMID:15477007 PMID:20479004 PMID:30218697
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