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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737364 Species: Homo sapiens RGD Object: Gene Symbol: PKLR Name: pyruvate kinase, liver and RBC

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:3336	6480464	CTD	Clofibrate affects the expression of PKLR mRNA	PMID:19483382
decreases expression	ISO	RGD:3336	6480464	CTD	Clofibrate results in decreased expression of PKLR mRNA	PMID:19224547 PMID:17522070
decreases expression	ISO	RGD:3336	6480464	CTD	Clofibrate results in decreased expression of PKLR protein	PMID:16470657
decreases expression	ISO	RGD:3336	6480464	CTD	Clofibrate results in decreased expression of PKLR mRNA	PMID:17522070 PMID:19224547
decreases expression	ISO	RGD:11113	6480464	CTD	Clofibrate results in decreased expression of PKLR mRNA	PMID:17585979