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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3affects expressionEXP 6480464CTDClofibrate affects the expression of NR1I3 mRNAPMID:19483382
Nr1i3increases expressionEXP 6480464CTDClofibrate results in increased expression of NR1I3 mRNAPMID:32741897
Nr1i3affects localizationISONr1i3 (Mus musculus)6480464CTDClofibrate affects the localization of NR1I3 proteinPMID:17962186
Nr1i3decreases expressionISONr1i3 (Mus musculus)6480464CTDClofibrate results in decreased expression of NR1I3 mRNAPMID:23811191
Nr1i3increases activityISONR1I3 (Homo sapiens)6480464CTDClofibrate results in increased activity of NR1I3 proteinPMID:28927721
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