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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61846 Species: Rattus norvegicus RGD Object: Gene Symbol: Psma4 Name: proteasome (prosome, macropain) subunit, alpha type 4

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:62138	6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSMA4 mRNA]	PMID:17585979
increases expression	ISO	RGD:62138	6480464	CTD	Clofibrate results in increased expression of PSMA4 mRNA	PMID:17585979
increases expression	EXP		6480464	CTD	Clofibrate results in increased expression of PSMA4 mRNA	PMID:21318169