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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1affects response to substanceEXP 6480464CTDGSTM1 affects the susceptibility to ClofibratePMID:16800819
Gstm1decreases expressionEXP 6480464CTDClofibrate results in decreased expression of GSTM1 mRNA; Clofibrate results in decreased expression of GSTM1 proteinPMID:11328961 PMID:16470657
Gstm1increases expressionISOGstm1 (Mus musculus)6480464CTDClofibrate results in increased expression of GSTM1 mRNA; Clofibrate results in increased expression of GSTM5 mRNAPMID:18723825 PMID:22496397
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