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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348983 Species: Homo sapiens RGD Object: Gene Symbol: POLE Name: polymerase (DNA directed), epsilon, catalytic subunit

Acc ID: CHEBI:36704 Term: imiquimod Definition: An imidazoquinoline that has formula C14H16N4. CasRN: 99011-02-6 Chemical ID: MESH:C056493

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:11127	6480464	CTD	imiquimod results in decreased expression of POLE mRNA	PMID:21878529