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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdkn1a Name: cyclin-dependent kinase inhibitor 1A

Acc ID: CHEBI:3638 Term: chloroquine Definition: A quinoline alkaloid that has formula C18H26ClN3. CasRN: 54-05-7 Chemical ID: MESH:D002738

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:735341	6480464	CTD	Chloroquine results in increased activity of CDKN1A	PMID:18089834
increases expression	ISO	RGD:735341	6480464	CTD	Chloroquine results in increased expression of CDKN1A protein	PMID:12243503