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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDChloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 proteinPMID:12082016 PMID:18089834
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDTRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]PMID:11589424
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]PMID:22927544
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