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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051 Species: Rattus norvegicus RGD Object: Gene Symbol: Tgfb1 Name: transforming growth factor, beta 1

Acc ID: CHEBI:35696 Term: cobalt dichloride Definition: Chloride of cobalt in which the metal is in the +2 oxidation state. CasRN: 7646-79-9 Chemical ID: MESH:C018021

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69095	6480464	CTD	cobaltous chloride promotes the reaction [TGFB1 protein results in increased expression of CTGF mRNA]	PMID:17034590
multiple interactions	ISO	RGD:69095	6480464	CTD	[cobaltous chloride co-treated with TGFB1 protein] results in increased secretion of VEGFA protein	PMID:10971326
decreases secretion	EXP		6480464	CTD	cobaltous chloride results in decreased secretion of TGFB1 protein	PMID:19520152
multiple interactions	EXP		6480464	CTD	cobaltous chloride affects the reaction [Oxygen deficiency results in increased expression of TGFB1 protein]	PMID:18635243