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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egln1increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of EGLN1 mRNA; cobaltous chloride results in increased expression of EGLN1 proteinPMID:22982409 PMID:24386269
Egln1affects expressionISOEgln1 (Mus musculus)6480464CTDcobaltous chloride affects the expression of EGLN1 mRNAPMID:14686790
Egln1decreases expressionISOEGLN1 (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of EGLN1 proteinPMID:22245592
Egln1increases expressionISOEGLN1 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of EGLN1 mRNAPMID:15695372 PMID:19502547 PMID:22202117
Egln1multiple interactionsISOEGLN1 (Homo sapiens)6480464CTDzinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EGLN1 mRNA]PMID:22202117
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