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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552738 Species: Mus musculus RGD Object: Gene Symbol: Pdk1 Name: pyruvate dehydrogenase kinase, isoenzyme 1

Acc ID: CHEBI:35696 Term: cobalt dichloride Definition: Chloride of cobalt in which the metal is in the +2 oxidation state. CasRN: 7646-79-9 Chemical ID: MESH:C018021

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:69480	6480464	CTD	cobaltous chloride results in increased expression of PDK1 mRNA	PMID:20105288
increases expression	ISO	RGD:69480	6480464	CTD	cobaltous chloride results in increased expression of PDK1 mRNA	PMID:19502547 PMID:20105288
multiple interactions	ISO	RGD:69480	6480464	CTD	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PDK1 mRNA]	PMID:22202117
increases expression	ISO	RGD:69480	6480464	CTD	cobaltous chloride results in increased expression of PDK1 mRNA	PMID:20105288 PMID:19502547 PMID:22202117
increases expression	ISO	RGD:69480	6480464	CTD	cobaltous chloride results in increased expression of PDK1 mRNA	PMID:19502547 PMID:20105288 PMID:22202117