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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of SIRT1 proteinPMID:22669716
Sirt1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]PMID:22669716
Sirt1increases expressionISOSIRT1 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of SIRT1 proteinPMID:22245592
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDSIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]]PMID:26174951
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