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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67decreases expressionISOMKI67 (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of MKI67 mRNAPMID:19320972 PMID:19376846
Mki67multiple interactionsISOMKI67 (Homo sapiens)6480464CTD[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA; [cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein]PMID:25192544
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