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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735634 Species: Mus musculus RGD Object: Gene Symbol: Scarb1 Name: scavenger receptor class B, member 1

Acc ID: CHEBI:35591 Term: pregnenolone 16alpha-carbonitrile Definition: A nitrile that has formula C22H31NO2. CasRN: 1434-54-4 Chemical ID: MESH:D011285

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:2302	6480464	CTD	Pregnenolone Carbonitrile results in decreased expression of SCARB1 protein	PMID:15883047
decreases expression	ISO	RGD:2302	6480464	CTD	Pregnenolone Carbonitrile results in decreased expression of SCARB1 mRNA	PMID:19162173 PMID:15883047
decreases expression	ISO	RGD:2302	6480464	CTD	Pregnenolone Carbonitrile results in decreased expression of SCARB1 mRNA	PMID:15883047 PMID:19162173