Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA; [Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA; allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in decreased expression of CYP1A2 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B1 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B2 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; Pregnenolone Carbonitrile binds to and results in increased activity of NR1I2 protein; Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]; Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]; sulforaphane inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]
[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA; NR1I2 gene promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]]
[Pregnenolone Carbonitrile binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 gene mutant form] results in decreased expression of PDK4 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of ABCC2 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of GSTT2 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of PAPSS2 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of SULT1E1 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of SULT3A1 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein] results in increased expression of CYP3A11 mRNA; [Pregnenolone Carbonitrile co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]] which results in increased expression of ALDH1A1 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]] which results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 gene]] which results in increased expression of CYP3A11 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]] which results in increased expression of GSTA1 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to PAPSS2 gene]] which results in increased expression of PAPSS2 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to SLCO1A4 gene]] which results in increased expression of SLCO1A4 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTA1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM2 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM3 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SLCO1A4 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of SULT2A1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A5 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A9 mRNA; Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of NR1I2 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 protein]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in decreased expression of AADAC mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in decreased expression of SLCO1A1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ALDH1A7 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CES2A mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CES2C mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA4 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM3 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of NR1I3 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of SLCO1A4 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of SULT2A2 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A9 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT2B34 mRNA]; NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of ATF3 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of CCL2 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of CYP4A10 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of FOS mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of HSPA1B mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of IL1B mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of IL1RN mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of IL6 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of MME mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of PF4 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C37 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A44 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of FOXM1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA2 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA4 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of KIF20A mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of RASAL1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of SLC39A5 mRNA]; Pregnenolone Carbonitrile binds to and results in increased activity of NR1I2 protein; Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 gene mutant form results in decreased expression of CYP4A10 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 3' UTR]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 5' UTR]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 intron]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP3A11 promoter]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTM1 5' UTR]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTM2 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to PAPSS2 gene]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to SLCO1A4 5' UTR]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to SLCO1A4 gene]
