GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i3 | decreases expression | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Pregnenolone Carbonitrile results in decreased expression of NR1I3 mRNA | PMID:27413110 | Nr1i3 | increases activity | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Pregnenolone Carbonitrile results in increased activity of NR1I3 protein | PMID:23850985 | Nr1i3 | increases expression | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Pregnenolone Carbonitrile results in increased expression of NR1I3 mRNA | PMID:25949234 | Nr1i3 | multiple interactions | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of NR1I3 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein] | PMID:19433268 PMID:25949234 | | ||||||||||||||||||||||
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