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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2decreases expressionISONr0b2 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in decreased expression of NR0B2 mRNAPMID:20359477
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in increased expression of NR0B2 mRNAPMID:22982774
Nr0b2multiple interactionsISONr0b2 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNAPMID:20359477
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