Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1increases expressionEXP 6480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNAPMID:19162173 PMID:22659317
Ugt1a1increases activityISOUGT1A1 (Homo sapiens)6480464CTDPregnenolone Carbonitrile results in increased activity of UGT1A1 proteinPMID:16155002 PMID:27413119
Ugt1a1increases expressionISOUgt1a1 (Mus musculus)6480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA; Pregnenolone Carbonitrile results in increased expression of UGT1A7 mRNAPMID:19144771 PMID:22496397 PMID:31388680
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA; Pregnenolone Carbonitrile results in increased expression of UGT1A1 proteinPMID:16155002 PMID:27413119
Ugt1a1multiple interactionsISOUgt1a1 (Mus musculus)6480464CTD[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A1 mRNA; Dexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]PMID:16155002 PMID:22496397
Go Back to source page   Continue to Ontology report