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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737091 Species: Homo sapiens RGD Object: Gene Symbol: HSD11B1 Name: hydroxysteroid (11-beta) dehydrogenase 1

Acc ID: CHEBI:35549 Term: perfluorooctanoic acid Definition: A fluoroalkanoic acid that has formula C8HF15O2. CasRN: 335-67-1 Chemical ID: MESH:C023036

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10734	6480464	CTD	perfluorooctanoic acid results in decreased expression of HSD11B1 mRNA	PMID:17681415
decreases expression	ISO	RGD:2834	6480464	CTD	perfluorooctanoic acid results in decreased expression of HSD11B1 mRNA	PMID:19162173 PMID:16221955
decreases expression	ISO	RGD:2834	6480464	CTD	perfluorooctanoic acid results in decreased expression of HSD11B1 mRNA	PMID:16221955 PMID:19162173
decreases activity	EXP		6480464	CTD	perfluorooctanoic acid results in decreased activity of HSD11B1 protein	PMID:22178014
decreases activity	ISO	RGD:2834	6480464	CTD	perfluorooctanoic acid results in decreased activity of HSD11B1 protein	PMID:22178014