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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628748
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adipoqdecreases expressionISOADIPOQ (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of ADIPOQ mRNAPMID:23146750
Adipoqincreases expressionISOAdipoq (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of ADIPOQ proteinPMID:34464680
Adipoqmultiple interactionsISOAdipoq (Mus musculus)6480464CTD[Dietary Fats co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid] results in increased expression of ADIPOQ protein; [perfluorooctanoic acid co-treated with Dietary Fats] results in increased expression of ADIPOQ protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of ADIPOQ protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid] results in increased expression of ADIPOQ protein; Dietary Fats inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid] results in increased expression of ADIPOQ protein]PMID:34464680
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