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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of NR1I3 mRNAPMID:28511854
Nr1i3decreases expressionISONr1i3 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of NR1I3 mRNAPMID:30657992
Nr1i3increases activityISONr1i3 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased activity of NR1I3 proteinPMID:30203046
Nr1i3increases expressionISONR1I3 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of NR1I3 mRNAPMID:25868421
Nr1i3increases expressionISONr1i3 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of NR1I3 mRNAPMID:18281256 PMID:30711707 PMID:32822737
Nr1i3increases localizationISONr1i3 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased localization of NR1I3 proteinPMID:27832320
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [perfluorooctanoic acid results in increased expression of CYP2B10 mRNA]; PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in increased expression of NR1I3 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of NR1I3 mRNA]PMID:18281256 PMID:27832320 PMID:32822737
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