GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | increases expression | EXP | | 6480464 | CTD | perfluorooctanoic acid results in increased expression of MMP2 protein | PMID:36849026 | Mmp2 | decreases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of MMP2 mRNA | PMID:32219433 PMID:32790152 | Mmp2 | increases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of MMP2 mRNA; perfluorooctanoic acid results in increased expression of MMP2 protein | PMID:24960061 PMID:29753068 PMID:36251517 | Mmp2 | multiple interactions | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [perfluorooctanoic acid results in increased expression of and results in increased activity of MMP2 protein]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [perfluorooctanoic acid results in increased expression of MMP2 mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [perfluorooctanoic acid results in increased expression of MMP2 protein]; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased activity of MMP2 protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of MMP2 mRNA; perfluorooctanoic acid results in increased expression of and results in increased activity of MMP2 protein; picropodophyllin inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased activity of MMP2 protein]; U 0126 inhibits the reaction [perfluorooctanoic acid results in increased expression of MMP2 mRNA]; U 0126 inhibits the reaction [perfluorooctanoic acid results in increased expression of MMP2 protein] | PMID:24960061 PMID:29753068 PMID:33571556 | |
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