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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acox1
Name: acyl-CoA oxidase 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1increases activityEXP 6480464CTDperfluorooctanoic acid results in increased activity of ACOX1 proteinPMID:14757943
Acox1increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of ACOX1 mRNA; perfluorooctanoic acid results in increased expression of ACOX1 proteinPMID:19162173 PMID:19407336 PMID:21723365 PMID:28511854 PMID:34958885 PMID:8011682
Acox1affects expressionISOAcox1 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of ACOX1 mRNAPMID:19429403
Acox1increases expressionISOACOX1 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of ACOX1 mRNAPMID:21723365 PMID:22425687 PMID:23978341
Acox1increases expressionISOAcox1 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of ACOX1 mRNAPMID:17681415 PMID:18281256 PMID:18467677 PMID:20936131 PMID:22154759 PMID:23143925 PMID:23626681 PMID:25092180 PMID:25949234 PMID:28558994 PMID:30657992 PMID:30711707 PMID:32822737 PMID:34252412
Acox1multiple interactionsISOAcox1 (Mus musculus)6480464CTDDietary Fats promotes the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]; Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]PMID:18281256 PMID:18467677 PMID:20936131 PMID:23143925 PMID:23626681 PMID:28558994 PMID:30711707 PMID:32822737
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