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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of CYP1A2 mRNA; perfluorooctanoic acid results in decreased expression of CYP1A2 proteinPMID:16221955 PMID:19162173 PMID:34958885
Cyp1a2affects expressionISOCyp1a2 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of CYP1A2 mRNAPMID:18281256
Cyp1a2affects expressionISOCYP1A2 (Homo sapiens)6480464CTDperfluorooctanoic acid affects the expression of CYP1A2 mRNAPMID:31809754
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased activity of CYP1A2 proteinPMID:31809754
Cyp1a2decreases expressionISOCyp1a2 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of CYP1A2 mRNAPMID:20118188
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of CYP1A2 mRNA]PMID:20118188
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