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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553279 Species: Mus musculus RGD Object: Gene Symbol: Hsp90aa1 Name: heat shock protein 90, alpha (cytosolic), class A member 1

Acc ID: CHEBI:35549 Term: perfluorooctanoic acid Definition: A fluoroalkanoic acid that has formula C8HF15O2. CasRN: 335-67-1 Chemical ID: MESH:C023036

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:631409	6480464	CTD	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	PMID:19162173
increases expression	EXP		6480464	CTD	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	PMID:21318169
increases expression	ISO	RGD:631409	6480464	CTD	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	PMID:21318169 PMID:19162173
multiple interactions	EXP		6480464	CTD	PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA]	PMID:21318169
increases expression	ISO	RGD:631409	6480464	CTD	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	PMID:19162173 PMID:21318169