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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases activityEXP 6480464CTDCadmium Chloride results in increased activity of MMP2 proteinPMID:20826145
Mmp2increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of MMP2 mRNAPMID:36493885
Mmp2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 mRNA]PMID:36493885
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of MMP2 proteinPMID:28830677
Mmp2increases expressionISOMmp2 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of MMP2 proteinPMID:25502771 PMID:28830677
Mmp2increases secretionISOMMP2 (Homo sapiens)6480464CTDCadmium Chloride results in increased secretion of MMP2 proteinPMID:27510461 PMID:28527916 PMID:30572105
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein; Cadmium Chloride results in increased secretion of and results in increased activity of MMP2 protein; Deoxyglucose inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]; ESR1 protein alternative form affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein]; GPER1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein]; HMGA2 protein affects the reaction [Cadmium Chloride results in increased expression of MMP2 protein]; KRAS protein promotes the reaction [Cadmium Chloride results in increased secretion of MMP2 protein]; Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]; PKM protein affects the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]PMID:23811327 PMID:27510461 PMID:28830677 PMID:29741670 PMID:31468104 PMID:34481905 PMID:34687772 PMID:36336208
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDtetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein]PMID:25502771
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