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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspd1
Name: heat shock protein family D (Hsp60) member 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspd1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of HSPD1 proteinPMID:21699967
Hspd1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of HSPD1 mRNAPMID:21297351
Hspd1affects expressionISOHSPD1 (Homo sapiens)6480464CTDCadmium Chloride affects the expression of HSPD1 mRNA; Cadmium Chloride affects the expression of HSPD1 proteinPMID:10802388
Hspd1decreases expressionISOHSPD1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of HSPD1 mRNA; Cadmium Chloride results in decreased expression of HSPD1 proteinPMID:18560533 PMID:24419708
Hspd1decreases expressionISOHspd1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of HSPD1 mRNAPMID:24982889
Hspd1increases expressionISOHSPD1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of HSPD1 mRNAPMID:12160620
Hspd1multiple interactionsISOHSPD1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPD1 proteinPMID:32142837
Hspd1multiple interactionsISOHspd1 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPD1 protein; [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSPD1 mRNA; Polystyrenes inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPD1 protein]PMID:19840844 PMID:37022104
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