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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1decreases expressionISOMCL1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of MCL1; Cadmium Chloride results in decreased expression of MCL1 mRNAPMID:21787858 PMID:33813002
Mcl1increases expressionISOMCL1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of MCL1 mRNA; Cadmium Chloride results in increased expression of MCL1 proteinPMID:12760830 PMID:34520792
Mcl1multiple interactionsISOMCL1 (Homo sapiens)6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of MCL1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MCL1 mRNA; STAT3 protein inhibits the reaction [Cadmium Chloride results in decreased expression of MCL1 mRNA]PMID:28949029 PMID:33813002 PMID:35301059
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