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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases response to substanceEXP 6480464CTDNFE2L2 protein results in decreased susceptibility to Cadmium ChloridePMID:19682480
Nfe2l2increases activityEXP 6480464CTDCadmium Chloride results in increased activity of NFE2L2 proteinPMID:19682480
Nfe2l2multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of NFE2L2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2L2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and affects the localization of NFE2L2 protein; [lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein; [protocatechuic acid co-treated with Cadmium Chloride] results in increased expression of NFE2L2 mRNA; [Sodium Selenite co-treated with zinc chloride] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which affects the localization of NFE2L2 protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2L2 protein]; GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride]; HMOX1 affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride]; NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased cleavage of CTSB protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased cleavage of CTSD protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CTSB mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CTSD mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CTSK mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CTSS mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; NFE2L2 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of LAMP1 protein]; NFE2L2 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of LAMP2 protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2L2 protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2L2 protein]PMID:19682480 PMID:32392679 PMID:34695510 PMID:36646412 PMID:36718047 PMID:36868496
Nfe2l2affects activityISONFE2L2 (Homo sapiens)6480464CTDCadmium Chloride affects the activity of NFE2L2 proteinPMID:25596134
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDCadmium Chloride affects the localization of NFE2L2 proteinPMID:16959797 PMID:20934533 PMID:21787730 PMID:24291162
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Cadmium ChloridePMID:19303893
Nfe2l2affects ubiquitinationISONfe2l2 (Mus musculus)6480464CTDCadmium Chloride affects the ubiquitination of NFE2L2 proteinPMID:18512965
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of NFE2L2 mRNAPMID:25596134
Nfe2l2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein results in decreased susceptibility to Cadmium Chloride; NFE2L2 results in decreased susceptibility to Cadmium ChloridePMID:18367636 PMID:18512965 PMID:22677785
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of NFE2L2 proteinPMID:15878868 PMID:20934533 PMID:28422390 PMID:30796460
Nfe2l2increases localizationISONfe2l2 (Mus musculus)6480464CTDCadmium Chloride results in increased localization of NFE2L2 proteinPMID:17303623
Nfe2l2increases stabilityISONfe2l2 (Mus musculus)6480464CTDCadmium Chloride results in increased stability of NFE2L2 proteinPMID:12441344
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2L2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased ubiquitination of NFE2L2 protein; Cadmium Chloride promotes the reaction [NFE2L2 protein binds to TXNRD1 promoter]; Cadmium Chloride results in increased expression of and affects the localization of NFE2L2 protein; diacetyldichlorofluorescein inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Ro 31-7549 inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]PMID:10874044 PMID:15521073 PMID:16959797 PMID:21787730 PMID:28229933 PMID:30359721 PMID:30796460 PMID:33040242 PMID:34352368 PMID:35122928 PMID:37325564
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to Cadmium Chloride]; [Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]] affects the localization of [NFE2L2 protein binds to KEAP1 protein]; [CYP2A5 promoter mutant form results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to Cadmium Chloride; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of NFE2L2 protein; [NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which affects the activity of GPT protein; [NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of CD68 mRNA; [NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of TNF mRNA; benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride affects the ubiquitination of NFE2L2 protein]; Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]; Cadmium Chloride inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]; Cadmium Chloride promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter]; Cadmium Chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; Cadmium Chloride promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Cadmium Chloride results in increased activity of and results in increased stability of NFE2L2 protein; Cadmium Chloride results in increased expression of and affects the localization of NFE2L2 protein; Cadmium Chloride results in increased expression of and results in increased activity of NFE2L2 protein; CTH protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 protein]; CTH protein affects the reaction [[NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which affects the activity of GPT protein]; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]; lactacystin promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of GCLM protein]; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]; NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[CTH protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which affects the activity of GPT protein]; NFE2L2 protein affects the reaction [Cadmium Chloride results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]; NFE2L2 protein promotes the reaction [Cadmium Chloride results in increased expression of CYP2A5 mRNA]; NFE2L2 protein promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Cadmium Chloride]PMID:10874044 PMID:12441344 PMID:15041070 PMID:17303623 PMID:18367636 PMID:18512965 PMID:20932822 PMID:22003191 PMID:26827822 PMID:29788535 PMID:30399392 PMID:31166132 PMID:33398418
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