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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects expressionEXP 6480464CTDCadmium Chloride affects the expression of CASP9 mRNAPMID:15842833
Casp9increases activityEXP 6480464CTDCadmium Chloride results in increased activity of CASP9 proteinPMID:16478757 PMID:16597613 PMID:16809017 PMID:18629305 PMID:19523979
Casp9increases cleavageEXP 6480464CTDCadmium Chloride results in increased cleavage of CASP9 proteinPMID:23405080 PMID:35525383
Casp9increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of CASP9 mRNA; Cadmium Chloride results in increased expression of CASP9 protein modified formPMID:28390674 PMID:31348969 PMID:35525383
Casp9multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased cleavage of CASP9 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP9 protein]; AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased activity of CASP9 protein]; CASR protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]; ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]; IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP9 protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA]PMID:16263807 PMID:18629305 PMID:23405080 PMID:26396915 PMID:28390674 PMID:32599263 PMID:34558789 PMID:34767868
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDCadmium Chloride results in increased activity of CASP9 proteinPMID:18850067 PMID:21420465 PMID:25409916
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDCadmium Chloride results in increased activity of CASP9 proteinPMID:16264267
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDCadmium Chloride results in increased cleavage of CASP9 proteinPMID:24419708
Casp9increases expressionISOCasp9 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CASP9 mRNA; Cadmium Chloride results in increased expression of CASP9 proteinPMID:25409916 PMID:28342888
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CASP9 mRNA; Cadmium Chloride results in increased expression of CASP9 protein; Cadmium Chloride results in increased expression of CASP9 protein modified formPMID:23941782 PMID:24291162 PMID:28342888 PMID:33129824
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; [Cadmium Chloride co-treated with Potassium Dichromate] results in increased activity of CASP9 protein; [Cadmium Chloride co-treated with Potassium Dichromate] results in increased expression of CASP9 mRNA; [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased activity of CASP9 protein; arjunolic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; Cadmium Chloride results in increased expression of and results in increased activity of CASP9 protein; caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of CASP9 protein]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]]; TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]PMID:18850067 PMID:21420465 PMID:25409916 PMID:28342888 PMID:30399392 PMID:34743973
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDCadmium Chloride promotes the reaction [Fluorouracil results in decreased expression of CASP9 mRNA]; Fluorouracil inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA]; TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]PMID:23941782 PMID:28342888
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