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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of PTGS1 mRNAPMID:25993096
Ptgs1decreases expressionISOPTGS1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of PTGS1 proteinPMID:25645360
Ptgs1increases expressionISOPTGS1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of PTGS1 mRNAPMID:25645360
Ptgs1multiple interactionsISOPTGS1 (Homo sapiens)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Cadmium Chloride results in increased expression of PTGS1 mRNA]PMID:25645360
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