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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein]PMID:34510229 PMID:35384154
Casp1increases cleavageISOCasp1 (Mus musculus)6480464CTDCadmium Chloride results in increased cleavage of CASP1 proteinPMID:30796460
Casp1increases cleavageISOCASP1 (Homo sapiens)6480464CTDCadmium Chloride results in increased cleavage of CASP1 proteinPMID:30796460 PMID:35650140
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CASP1 mRNAPMID:30796460
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP1 proteinPMID:30796460 PMID:33359024
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA]; [Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein]; MitoTEMPO inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; XBP1 protein affects the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; XBP1 protein alternative form inhibits the reaction [SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]]PMID:26809137 PMID:30796460 PMID:34510229 PMID:37300869
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