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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k4increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of MAP2K4 proteinPMID:18021293 PMID:18703135
Map2k4multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]PMID:18703135
Map2k4increases phosphorylationISOMAP2K4 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of MAP2K4 proteinPMID:18703135
Map2k4multiple interactionsISOMAP2K4 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]PMID:18703135
Map2k4multiple interactionsISOMap2k4 (Mus musculus)6480464CTD[MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; MAPK11 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]PMID:18348256
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